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Neurotrophic effect of fish-lecithin based nanoliposomes on cortical neurons

Marine Drugs, 17 (7), 406

Malaplate, C., Poerio, A., Huguet, M., Soligot, C., Passeri, E., Kahn, C.J.F., Linder, M., Arab-Tehrany, E., Yen, F.T.

2019

Lipids play multiple roles in preserving neuronal function and synaptic plasticity, and polyunsaturated fatty acids (PUFAs) have been of particular interest in optimizing synaptic membrane organization and function. We developed a green-based methodology to prepare nanoliposomes (NL) from lecithin extracted from fish head by-products. These NL range between 100-120 nm in diameter, with an n-3/n-6 fatty acid ratio of 8.88. The high content of n-3 PUFA (46.3% of total fatty acid content) and docosahexanoic acid (26%) in these NL represented a means for enrichment of neuronal membranes potentially beneficial for neuronal growth and synaptogenesis. To test this, primary cultures of rat embryo cortical neurons were incubated with NL on day 3 post-culture for 24h, followed by immunoblots or immunofluorescence to evaluate NL effects on synaptogenesis, axonal growth and dendrite formation. Results revealed that NL-treated cells on day 4 displayed a level of neurite outgrowth and arborization similar to those of untreated cells on day 5 and 6, suggesting accelerated synapse formation and neuronal development in the presence of NL. We propose that fish-derived NL, by virtue of their n-3 PUFA profile and neurotrophic effects, represent a new innovative bioactive vector for developing preventive or curative treatments of neurodegenerative diseases.

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