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RP2E INRA Université de Lorraine

Publications

Modifications of the endosomal compartment in peripheral blood mononuclear cells and fibroblasts from Alzheimer's disease patients

Transl Psychiatry., 5, e595.

Corlier, F., Rivals, I., Lagarde, J., Hamelin, L., Corne, H., Dauphinot, L., Ando, K., Cossec, J.-C., Fontaine, G., Dorothée, G., Malaplate-Armand, C., Olivier, J.-L., Dubois, B., Bottlaender, M., Duyckaerts, C., Sarazin, M., Potier, M.-C., ImaBio3

2015

Identification of blood-based biomarkers of Alzheimer's disease (AD) remains a challenge. Neuropathological studies have identified enlarged endosomes in post-mortem brains as the earliest cellular change associated to AD. Here the presence of enlarged endosomes was investigated in peripheral blood mononuclear cells from 48 biologically defined AD patients (25 with mild cognitive impairment and 23 with dementia (AD-D)), and 23 age-matched healthy controls using immunocytochemistry and confocal microscopy. The volume and number of endosomes were not significantly different between AD and controls. However, the percentage of cells containing enlarged endosomes was significantly higher in the AD-D group as compared with controls. Furthermore, endosomal volumes significantly correlated to [C(11)]PiB cortical index measured by positron emission tomography in the AD group, independently of the APOE genotype, but not to the levels of amyloid-beta, tau and phosphorylated tau measured in the cerebrospinal fluid. Importantly, we confirmed the presence of enlarged endosomes in fibroblasts from six unrelated AD-D patients as compared with five cognitively normal controls. This study is the first, to our knowledge, to report morphological alterations of the endosomal compartment in peripheral cells from AD patients correlated to amyloid load that will now be evaluated as a possible biomarker.

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212 Publications depuis 2013

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2019

ACL - Articles comité de lecture référencés bases de données HCÉRES

  • Adhesion Properties of Probiotic Lactobacillus strains Isolated from Tunisian Sheep and Goat Milks

    Journal of Agricultural Science and Technology, 21 (4), pp. pp-pp.

    Mahmoudi, I., Ben moussa, O., Khaldi, T. E. M., Kebouchi, M., Soligot-Hognon, C., Le Roux, Y., Hassouna, M.

  • Simulating rewetting events in intermittent rivers and ephemeral streams: a global analysis of leached nutrients and organic matter

    Global Change Biology, vv (nn), pp. pp-pp.

    Shumilova, O., Zak, D., Datry, T., Von schiller, D., Corti, R., Foulquier, A., Obrador, B., Tockner, K., Altermatt, F., Isabel arce, M., Arnon, S., Banas, D., Banegas-medina, A., Beller, E., Blanchette, M., Blanco-libreros, J.F., Blessing, J., Gonçalves boëchat, I., Boersma, K., Bogan, M.T., Bonada, N., Bond, N., Brintrup, K., Bruder, A., Burrows, R., Cancellario, T., Carlson, S.M., Cauvy-fraunié, S., Cid, N., Danger, M., De freitas terra, B., De girolamo, A.M., Del campo, R., Dyer, F., Elosegi, A., Emile, F., Febria, C., Figueroa, R., Four, B., Gessner, M.O., Gnohossou, P., Gómez cerezo, R., Gómez-gener, L., Graça, M.A.S., Guareschi, S., Gücker, B., Hwan, J.L., Kubheka, S., Langhans, S.D., Leigh, C., Little, C., Lorenz, S., Marshall, J., Mcintosh, A., Mendoza-lera, C., Meyer, E.I., Miliša, M., Mlambo, M.C., Moleón, M., Negus, P., Niyogi, D., Papatheodoulou, A., Pardo, I., Paril, P., Peši?, V., Rodríguez-lozano, P., Rolls, R.R., Sánchez-montoya, M.M., Savi?, A., Steward, A., Stubbington, R., Taleb, A., Vander vorste, R., Waltham, N., Zoppini, A., Zarfl, C.

2018

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2017

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2016

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2015

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2014

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2013

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