Time-Temperature Integrator (TTI) systems based on Bacillus licheniformis a-amylase (BLA), sucrose and salts immobilized at the surface of non-porous glass beads (inert filler) and under several low moisture conditions (aw in the range 0-0.63 after equilibrium at 4 °C) were studied. These systems showed interesting thermal stabilities in the range 100-132 °C under isothermal conditions. More precisely, the TTI system equilibrated at a w=0.48 (BLAGB48) showed capabilities, under non-isothermal conditions, for monitoring the process value zTTI=9.4°CF121.1°C in the range 0-30 min with an absolute average % error of 14%. Although this error is comparable to already reported systems, this TTI showed numerous advantages over the latter: (i) The time required for the moisture equilibration of the systems was significantly reduced (2-3 days instead of 3 weeks). (ii) The aggregation of the a-amylase during heating could be overcome enhancing the solubilization of the a-amylase after heat treatment in only 1 min. (iii) Consequently, it became possible to use convenient residual activity reading method (only 5 min required) instead of a residual heat denaturation enthalpy reading (15 min required) as a response property of the system. (iv) The amount of a-amylase required per TTI was 50-fold smaller. (v) Finally, larger thermal impacts (process values up to 30 min) could be monitored.