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RP2E INRA Université de Lorraine

Structure-function relationship in modular PKSs and their application to genetic engineering

MegaSyn Symposium, 29 septembre - 01 octobre, Bad Nauheim, Allemagne 2020

Weissman, K.J., Risser, F., Massicart, J.-M., Collin, S., Dos Santos Morais, R., Soligot-Hognon, C., Jacob, C., Gruez, A., Chagot, B.

2020

Despite decades of effort, attempts to manipulate modular PKSs using synthetic biology remain
hampered by limited structure-function relationship information for these megaenzymes. This talk will
showcase our recent work on several aspects of modular PKS architecture and function, and how the
resulting information can be leveraged to generate defined polyketide derivatives.

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