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RP2E INRA Université de Lorraine

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Comparison of chlordecone and NDL-PCB decontamination dynamics in growing male kids after cessation of oral exposure: Is there a potential to decrease the body levels of these pollutants by dietary supplementation of activated carbon or paraffin oil?

Chemoshpere, 193 (-), pp. 100-107.

Lastel, M.-L., Fournier, A., Jurjanz, S., Thomé, J.-P., Joaquim-Justo, C., Archimède, H., Mahieu, M., Feidt, C., Rychen, G.

2018

Sixteen weaned male Alpine kids (Capra hircus) were subjected to a 21-day oral daily exposure of
0.05 mg kg1 BW. d1 of chlordecone (CLD) and 0.30 mg kg1 BW. d1 of each non-dioxin-like polychlorinated
biphenyls (NDL-PCBs, congeners 28, 52, 101, 138, 153 and 180). Four kids, identified as the
CONTA group, were slaughtered at the end of the exposure, while the remaining animals (n ¼ 12) were
fed with specific diets for an additional 21-day decontamination period before slaughtering. Kids from
the DECONTA (n ¼ 4) group were fed a control diet, while those from the AC10% and PO8% group
received pellets supplemented with 10% activated carbon (AC) and 8% paraffin oil (PO), respectively. CLD
and NDL-PCB levels in blood, liver, peri-renal fat and muscles from different groups were analysed to
compare the decontamination dynamics of the pollutants and to determine the efficiency of AC and PO to
decrease the body levels of pollutants.
After the decontamination period, the CLD levels considerably decreased (more than 60%) in blood,
liver, muscles and fat. Concerning NDL-PCBs, the decontamination process was much lower. Overall, CLD
appeared to be less retained in kids’ organism compared with NDL-PCBs, and the decontamination
dynamics of these pollutants appeared to be different because of their specific physicochemical properties
and lipophilicity. Furthermore, the dietary supplementation with AC or PO did not significantly
affect the decontamination dynamics.

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