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RP2E INRA Université de Lorraine

Publications

Disialylated apolipoprotein C-III proteoform is associated with improved lipids in prediabetes and type 2 diabetes

Journal of Lipid Research, 57 (5), pp. 894-904.

Koska, J., Yassine, H., Trenchesvka, O., Sinari, S., Schwenke, D.-C., Yen, F.T., Billheimer, D., Nelson, R.-W., Nedelkov, D., Reaven, P.-D.

2016

The apoC-III proteoform containing two sialic acid residues (apoC-III2) has different in vitro effects on lipid metabolism compared with asialylated (apoC-III0) or the most abundant monosialylated (apoC-III1) proteoforms. Cross-sectional and longitudinal associations between plasma apoC-III proteoforms (by mass spectrometric immunoassay) and plasma lipids were tested in two randomized clinical trials: ACT NOW, a study of pioglitazone in subjects with impaired glucose tolerance (n = 531), and RACED (n = 296), a study of intensive glycemic control and atherosclerosis in type 2 diabetes patients. At baseline, higher relative apoC-III2 and apoC-III2/apoC-III1 ratios were associated with lower triglycerides and total cholesterol in both cohorts, and with lower small dense LDL in the RACED. Longitudinally, changes in apoC-III2/apoC-III1 were inversely associated with changes in triglycerides in both cohorts, and with total and small dense LDL in the RACED. apoC-III2/apoC-III1 was also higher in patients treated with PPAR-gamma agonists and was associated with reduced cardiovascular events in the RACED control group. Ex vivo studies of apoC-III complexes with higher apoC-III2/apoC-III1 showed attenuated inhibition of VLDL uptake by HepG2 cells and LPL-mediated lipolysis, providing possible functional explanations for the inverse association between a higher apoC-III2/apoC-III1 and hypertriglyceridemia, proatherogenic plasma lipid profiles, and cardiovascular risk.

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212 Publications depuis 2013

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2019

ACL - Articles comité de lecture référencés bases de données HCÉRES

  • Adhesion Properties of Probiotic Lactobacillus strains Isolated from Tunisian Sheep and Goat Milks

    Journal of Agricultural Science and Technology, 21 (4), pp. pp-pp.

    Mahmoudi, I., Ben moussa, O., Khaldi, T. E. M., Kebouchi, M., Soligot-Hognon, C., Le Roux, Y., Hassouna, M.

  • Simulating rewetting events in intermittent rivers and ephemeral streams: a global analysis of leached nutrients and organic matter

    Global Change Biology, vv (nn), pp. pp-pp.

    Shumilova, O., Zak, D., Datry, T., Von schiller, D., Corti, R., Foulquier, A., Obrador, B., Tockner, K., Altermatt, F., Isabel arce, M., Arnon, S., Banas, D., Banegas-medina, A., Beller, E., Blanchette, M., Blanco-libreros, J.F., Blessing, J., Gonçalves boëchat, I., Boersma, K., Bogan, M.T., Bonada, N., Bond, N., Brintrup, K., Bruder, A., Burrows, R., Cancellario, T., Carlson, S.M., Cauvy-fraunié, S., Cid, N., Danger, M., De freitas terra, B., De girolamo, A.M., Del campo, R., Dyer, F., Elosegi, A., Emile, F., Febria, C., Figueroa, R., Four, B., Gessner, M.O., Gnohossou, P., Gómez cerezo, R., Gómez-gener, L., Graça, M.A.S., Guareschi, S., Gücker, B., Hwan, J.L., Kubheka, S., Langhans, S.D., Leigh, C., Little, C., Lorenz, S., Marshall, J., Mcintosh, A., Mendoza-lera, C., Meyer, E.I., Miliša, M., Mlambo, M.C., Moleón, M., Negus, P., Niyogi, D., Papatheodoulou, A., Pardo, I., Paril, P., Peši?, V., Rodríguez-lozano, P., Rolls, R.R., Sánchez-montoya, M.M., Savi?, A., Steward, A., Stubbington, R., Taleb, A., Vander vorste, R., Waltham, N., Zoppini, A., Zarfl, C.

2018

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2017

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2016

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2015

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2014

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2013

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