english
français
RP2E INRA Université de Lorraine

Publications

Increased Susceptibility of Dyslipidemic LSR+/- Mice to Amyloid Stress is Associated with Changes in Cortical Cholesterol Levels

J Alzheimers Dis, 45 (1), pp. 195-204.

Pincon, A., Thomas, M., Huguet, M., Allouche, A., Colin, J., Georges, A., Derrien, A., Lanhers, M.-C., Malaplate-Armand, C., Oster, T., Corbier, C., Pillot, T., Olivier, J.-L., Yen, F.T.

2015

Alzheimer’s disease (AD) is a neurodegenerative disease that has been linked to changes in cholesterol metabolism. Neuronal cholesterol content significantly influences the  pro-apoptotic effect of amyloid-beta peptide42 (Abeta42), which plays a key role in AD development. We previously reported that aged mice with reduced expression of the lipolysis stimulated lipoprotein receptor (LSR+/−), demonstrate membrane cholesterol accumulation and decreased intracellular lipid droplets in several brain regions, suggesting a potential role of LSR in brain cholesterol distribution.We questioned if these changes rendered the LSR+/− mouse more susceptible to Abeta42-induced cognitive and biochemical changes. Results revealed that intracerebroventricular injection of oligomeric Abeta42 in male 15-month old LSR+/+ and LSR+/− mice led to impairment in learning and long-term
memory and decreased cortical cholesterol content of both groups; these effects were significantly amplified in the Abeta42- injected LSR+/− group. Total latency of the Morris test was significantly and negatively correlated with cortical cholesterol content of the LSR+/− mice, but not of controls. Significantly lower cortical PSD95 and SNAP−25 levels were detected in Abeta42-injected LSR+/− mice as compared to Abeta42-injected LSR+/+ mice. In addition, 24S-hydroxy cholesterol metabolite levels were significantly higher in the cortex of LSR+/− mice. Taken together, these results suggest that changes in cortex cholesterol regulation as a result of the LSR+/− genotype were linked to increased  susceptibility to amyloid stress, and we would therefore propose the aged LSR+/− mouse as a new model for understanding the link between modified cholesterol regulation as risk
factor for AD.

Imprimer le document

214 Publications depuis 2013

Imprimer le listing

2019

ACL - Articles comité de lecture référencés bases de données HCÉRES

  • Adhesion Properties of Probiotic Lactobacillus strains Isolated from Tunisian Sheep and Goat Milks

    Journal of Agricultural Science and Technology, 21 (4), pp. pp-pp.

    Mahmoudi, I., Ben moussa, O., Khaldi, T. E. M., Kebouchi, M., Soligot-Hognon, C., Le Roux, Y., Hassouna, M.

  • Simulating rewetting events in intermittent rivers and ephemeral streams: a global analysis of leached nutrients and organic matter

    Global Change Biology, vv (nn), pp. pp-pp.

    Shumilova, O., Zak, D., Datry, T., Von schiller, D., Corti, R., Foulquier, A., Obrador, B., Tockner, K., Altermatt, F., Isabel arce, M., Arnon, S., Banas, D., Banegas-medina, A., Beller, E., Blanchette, M., Blanco-libreros, J.F., Blessing, J., Gonçalves boëchat, I., Boersma, K., Bogan, M.T., Bonada, N., Bond, N., Brintrup, K., Bruder, A., Burrows, R., Cancellario, T., Carlson, S.M., Cauvy-fraunié, S., Cid, N., Danger, M., De freitas terra, B., De girolamo, A.M., Del campo, R., Dyer, F., Elosegi, A., Emile, F., Febria, C., Figueroa, R., Four, B., Gessner, M.O., Gnohossou, P., Gómez cerezo, R., Gómez-gener, L., Graça, M.A.S., Guareschi, S., Gücker, B., Hwan, J.L., Kubheka, S., Langhans, S.D., Leigh, C., Little, C., Lorenz, S., Marshall, J., Mcintosh, A., Mendoza-lera, C., Meyer, E.I., Miliša, M., Mlambo, M.C., Moleón, M., Negus, P., Niyogi, D., Papatheodoulou, A., Pardo, I., Paril, P., Peši?, V., Rodríguez-lozano, P., Rolls, R.R., Sánchez-montoya, M.M., Savi?, A., Steward, A., Stubbington, R., Taleb, A., Vander vorste, R., Waltham, N., Zoppini, A., Zarfl, C.

2018

ACL - Articles comité de lecture référencés bases de données HCÉRES

ACLN - Articles comité de lecture non-référencés bases de données HCÉRES

2017

ACL - Articles comité de lecture référencés bases de données HCÉRES

ACLN - Articles comité de lecture non-référencés bases de données HCÉRES

2016

ACL - Articles comité de lecture référencés bases de données HCÉRES

2015

ACL - Articles comité de lecture référencés bases de données HCÉRES

ACLN - Articles comité de lecture non-référencés bases de données HCÉRES

2014

ACL - Articles comité de lecture référencés bases de données HCÉRES

ACLN - Articles comité de lecture non-référencés bases de données HCÉRES

2013

ACL - Articles comité de lecture référencés bases de données HCÉRES

ACLN - Articles comité de lecture non-référencés bases de données HCÉRES

Voir les productions antérieures

Toutes les productions scientifiques